PUBLICATIONS
Studies in selected areas
Helplifes has spent more than forty years investigating the safety and efficacy of our probiotic strains. We conduct state-of-the-art preclinical and clinical studies, to evaluate the health effects and underlying mechanisms of our probiotics. Our scientists, and research groups, have published hundreds of studies on functional probiotics, covering various fields from digestive health to chronic disease management health.
Beneath we present a few of our studies in selected areas.
Bifidobacterium longum CCFM760 Function: Relieve constipation Article: Physiological Characteristics, Safety Evaluation and Genetic Analysis of Bifidobacterium longum CCFM760 Screening and Probiotic Characteristics Analysis of Bifidobacteria with Relieving Constipation Author: Ying Congping Journal: Journal of Food Science and Biotechnology Vol.39 Issue 2 2020 |
Lactobacillus plantarum CCFM1143 Function: Protective effect on diarrhea Article: Lactobacillus plantarum relieves diarrhea caused by enterotoxin-producing Escherichia coli through inflammation modulation and gut microbiota regulation Author: Yue Yue Journal: Food & Function 2020 |
Bifidobacterium longum subsp. longum YS108R Function: Alleviates DSS-induced colitis Article: A ropy exopolysaccharide producing strain Bifidobacterium longum subsp. longum YS108R alleviates DSS-induced colitis by maintenance of the mucosal barrier and gut microbiota modulation Author: Shuang Yan Journal: Food & Function 2019 |
Lactobacillus gasseri Chen, and L. plantarum 18 Function: Significant anti-H.pylori activity Article: Antagonistic Activities of Lactobacilli against Helicobacter pylori Growth and Infection in Human Gastric Epithelial Cells Author: Xiaohua Chen Journal: Journal of Food Science |
Bacillus coagulans-39 Function: relieved constipation Article: MLST analysis of genetic diversity of Bacillus coagulans strains to evaluate effects on constipation model Author: Jiang Cao Journal: Food science and Human Wellness |
Bifidobacterium breve CCFM1026 Function: Relieving respiratory infections Article: The Potential Role of Probiotics in Protection against Influenza a Virus Infection in Mice Author: Wenwei Lu Journal: Foods 2021 Apr 20 |
Streptococcus thermophilus CCFM218 (ST218) Function: Alleviate allergic responses treated with antibiotics Article: Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation Author: Q. Zhang Journal: Journal of Applied Microbiology 119, 809–817 © 2015 |
Lactobacillus reuteri CCFM1072 and CCFM1040 Function: Alleviate allergic asthma Article: Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice Author: Lingzhi Li Journal: Journal of Functional Foods 2020-11 |
Bifidobacterium longum CCFM1029 Function: Alleviate 2, 4-dinitrofluorobenzene-induced AD Article: Strain-specific ameliorating effect of Bifidobacterium longum on atopic dermatitis in mice Author: Zhifeng Fang Journal: Journal of Functional Foods |
Lactobacillus plantarum LP01/ Lactobacillus paracasei LPC00 Function: Treatment of Allergic Rhinitis Article: Multi-strain Symbiotic Preparations as a Novel Adjuvant Approach to Allergic Rhinitis Author: Giuseppina Manzotti Journal: Columbia International Publishing Journal of Contemporary Immunology Oct-14 |
Lactococcus lactis LL- DM Function: Alleviated Der p2-induced airway inflammation,inhibit allergic responses Article: Suppression of dust mite allergy by mucosal delivery of a hypoallergenic derivative in a mouse model Author: Chunqing Ai |
Lactobacillus casei CCFM1074 Function: Alleviates Collagen-Induced Arthritis Author: Zhexin Fan Article: Lactobacillus casei CCFM1074 Alleviates Collagen-Induced Arthritis in Rats via Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota Journal: Frontiers in immunology 2021 |
Bifidobacterium animalis CCFM1148 Function: Ameliorate psoriasis. Author: Yadan Deng Article: Evaluation of probiotics for inhibiting hyperproliferation and inflammation relevant to psoriasis in vitro Journal: Journal of Functional Foods 2021 |
Lactobacillus rhamnosus CCFM0528 Function: A promising therapeutic agent in treating type 2 diabetes Article: Oral administration of Lactobacillus rhamnosus CCFM0528 improves glucose tolerance and cytokine secretion in high-fat-fed, streptozotocin-induced type 2 diabetic mice Author: Pei Chen |
Lactobacillus casei CCFM0412 Function: Prevention of type 2 diabetes. Article: Antidiabetic effect of Lactobacillus casei CCFM0412 on mice with type 2 diabetes induced by a high-fat diet and streptozotocin Author: Pei Chen |
Lactobacillus fermentum 5-1L Function: Relieving osteoporosis Article: Development and functional evaluation of probiotics with the effect of relieving osteoporosis Author: Jiang Peng |
Lactobacillus rhamnosus L7-1 Function: alleviate non-alcoholic fatty liver disease Article: Bifidobacterium adolescentis and Lactobacillus rhamnosus alleviate non-alcoholic fatty liver disease induced by a high-fat, high-cholesterol diet through modulation of different gut microbiota-dependent pathways Author: Gang Wang |
Lactobacillus crispatus CCFM1110 Function: Prevention and/or treatment of candida vaginitis Article: A strain of Lactobacillus crispatus that prevents and/or treats candida vaginitis. Comparative Genomics of Lactobacillus crispatus from the Gut and Vagina Reveals Genetic Diversity and Lifestyle Adaptation. Lactobacillus crispatus inhibiting Candida albicans proliferation and regulating immune response to alleviate vulvovaginal candidiasis Author: Qiuxiang Zhang |
Lactobacillus gasseri CCFM1213 Function: Inhibit gardnerella vaginalis Article: Inhibitory effect of Lactobacillus gasseri CCFM1213 on Gardnerella vaginalis in mice with bacterial vaginosis |
Lactobacillus plantarum CCFM1019 (Lactobacillus plantarum HL2) Function: Alleviates polycystic ovary syndrome Article: Lactobacillus plantarum CCFM1019 attenuate polycystic ovary syndrome through butyrate dependent gut-brain mechanism |
Bifidobacterium longum CCFM1102 (Bifidobacterium longum HB3) Function: Alleviates polycystic ovary syndrome Article: Lactic acid bacteria alleviate polycystic ovarian syndrome by regulating sex hormone related gut microbiota Author: Yufeng He Journal: Food & Function 2020 |
Lactobacillus plantarum CCFM1180 (Lactobacillus plantarum 30M5 ) Function: Relieve the symptoms of female menopause caused by estrogen deficiency Article: Modulation of the gut microbiota structure with probiotics and isoflavone alleviates metabolic disorder in ovariectomized mice Author: Qian Chen |
Lactobacillus plantarum CCFM8724 Function: Treatment and prevention of dental caries induced by S. mutans and C. albicans. Article: Inhibitory Effect of Lactobacillus plantarum CCFM8724 towards Streptococcus mutans- and Candida albicans-Induced Caries in Rats Author: Qiuxiang Zhang |
Lactobacillus fermentum CCFM1139 Function: protect against periodontitis Article: Effects of Limosilactobacillus fermentum CCFM1139 on experimental periodontitis in rats Author: Qiuxiang Zhang |